Star Metro - Onco-Innovations Progresses Toward IND Preparation as Nucro-Technics Commences Bioanalysis for PNKP Inhibitor Technology

Nucro-Technics has begun developing and executing specialized liquid chromatography-mass spectrometry (LC-MS) analytical methods² required to measure the API within biological samples generated during the animal model study. These analytical tools will allow researchers to accurately assess how the compound behaves in vivo, supporting a deeper understanding of its exposure, distribution, and potential therapeutic relevance. Although highly technical, this work provides the essential measurement capabilities on which meaningful PK and biodistribution insights depend.

The start of this analytical phase marks a natural progression of Onco's preclinical program, enabling the Company to generate the datasets needed to refine dosing strategies, inform formulation work, and prepare for subsequent GLP-compliant studies. This stage builds upon earlier development efforts and strengthens the foundation of the Company's IND-enabling plan (see Company press release dated September 28, 2025).

"The initiation of this analytical phase gives us the capability to generate the data that truly drives decision-making in early drug development. It allows us to understand how our PNKP inhibitor behaves in vivo and ensures that each subsequent study is grounded in high-quality evidence. This is the type of foundational work that moves a program from concept toward a real clinical candidate," said Thomas O'Shaughnessy, CEO of Onco-Innovations.

Nucro-Technics will continue method development, perform non-GLP analyses, and deliver the corresponding reports in alignment with the study's operational timelines. This coordinated effort supports Onco's broader goal of advancing the Technology toward clinical evaluation and expanding the pipeline of next-generation DNA Damage Response Inhibitor (DDRi) therapies.

About Onco-Innovations Limited

Onco-Innovations is a Canadian-based company dedicated to cancer research and treatment, specializing in oncology. Onco's mission is to pursue the prevention and treatment of cancer through pioneering research and innovative solutions. The company has secured an exclusive worldwide license to patented technology that targets solid tumours.

ON BEHALF OF ONCO-INNOVATIONS LIMITED,

"Thomas O'Shaughnessy"
Chief Executive Officer

For more information, please contact:

Thomas O'Shaughnessy
Chief Executive Officer
Tel: + 1 888 261 8055
[email protected]

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View the original press release on ACCESS Newswire

S.Cloutier--SMC